Association of MBL2-gene polymorphism with asthma after bronchiolitis in infancy.
The New Perspective of Pathophysiology and Immunology Profile in Chronic Rhinosinusitis.
Koponen P, et al.
Pediatr Int. 2012 Apr 18.
Background: Mannose-binding lectin (MBL) is a component of innate immunity and has been linked with the pathogenesis of asthma. We evaluated the association of MBL genotypes with preschool asthma and allergy in children with bronchiolitis in early infancy. Methods: In all, 205 infants were hospitalized for bronchiolitis at <6 months of age. Asthma and allergy were studied from a total of 166 children at 6.4 years (mean). 141(85%) frozen whole blood samples were available for MBL genotyping MBL2 gene mutations were determined by pyrosequencing for detection of three single nucleotide polymorphisms. Results: Ninety-five (67.4%) children had the wild-type MBL genotype A/A and 46 had A/O or O/O genotypes. Asthma was present in 16 (11.3%) children at 5-7 years of age. Nine (19.6%) children with non-AA genotype had asthma (vs. 7.4% of those with genotype AA, p=0.03). The result remained significant after adjustment with age, gender and atopy. There were no significant associations between MBL genotypes and asthma at any age before the study. Atopic dermatitis, allergic rhinitis or parental/maternal asthma had no significant associations with MBL genotypes.
Conclusions: The variant non-A/A MBL genotype is associated with asthma after bronchiolitis in infancy, but not earlier than at 5-7 years of age.
Source: Paediatric Research Centre, Tampere University and University Hospital, Finland; Department of Infectious Disease Surveillance and Control, National Institute of Health and Welfare, Turku, Finland.
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